CASE 1: A 37-year-old man who presented with a PSA level of 37 ng/mL, a palpable prostate nodule and Gleason 4 + 3 prostate cancer
From the practice of Thomas E Keane, MBBCh
Chairman and Professor, Medical University of South Carolina
Department of Urology, Charleston, South Carolina

CASE 2: A 50-year-old man who presented with an initial-screening PSA level of 47 ng/mL, a 120-g prostate and Gleason 8 and 9 prostate cancer with possible rectal wall invasion
From the practice of Leonard G Gomella, MD
The Bernard W Godwin Professor of Prostate Cancer
Chairman, Department of Urology, Jefferson Medical College
Director of Urologic Oncology, Kimmel Cancer Center, Philadelphia, Pennsylvania

CASE 3: A 55-year-old man who presented three years ago with T3, Gleason 9, locally advanced prostate cancer and who refused surgery and hormone therapy
From the practice of Michael J Zelefsky, MD
Chief, Brachytherapy Service
Memorial Sloan-Kettering Cancer Center, New York, New York

CASE 4: A 60-year-old man diagnosed with Gleason 6 and 7 prostate cancer and metastases in the ribs and spine
From the practice of Judd W Moul, MD
Professor and Chief, Division of Urologic Surgery,
Duke University Medical Center, Durham, North Carolina

CASE 5: A 46-year-old man with a strong family history of prostate cancer and an initial PSA level of 15 ng/mL. Ten out of 12 biopsies were positive for Gleason 7 prostate cancer. Radical prostatectomy revealed extensive disease, positive margins and minimal seminal vesicle invasion
From the practice of E David Crawford, MD
Professor of Surgery and Radiation Oncology
Head, Urologic Oncology, University of Colorado
Health Sciences Center, Aurora, Colorado

CASE 6: A 50-year-old man who underwent robotic prostatectomy revealing Gleason 8 prostate cancer with seminal vesicle involvement but negative margins
From the practice of Mary-Ellen Taplin, MD
Assistant Professor of Medicine, The Lank Center for Genitourinary Oncology
Dana-Farber Cancer Institute, Boston, Massachusetts

CASE 7 (audio only): A 63-year-old man with Gleason 4 + 3, node-positive prostate cancer and a PSA of 160 ng/mL
From the practice of Stephen J Freedland, MD
Attending Physician, Durham VA Medical Center
Assistant Professor of Urology and Pathology,
Duke University School of Medicine, Durham, North Carolina

CASE 8: A patient with positive nodes postprostatectomy treated with hormonal therapy and radiation therapy
From the practice of Mack Roach III, MD
Professor, Radiation Oncology and Urology
Chairman, Department of Radiation Oncology,
UCSF Comprehensive Cancer Center, San Francisco, California

CASE 9: A 67-year-old man who underwent radical prostatectomy for Gleason 5 + 3 prostate cancer with extracapsular extension and negative margins
From the practice of Dr Moul

CASE 10: A 75-year-old man with a history of radical prostatectomy at age 65 and a steady PSA doubling time of two years to a level of 1.0 ng/mL
From the practice of Dr Freedland, MD

Case 11 (audio only): A man in his early fifties with Gleason 6, node-negative prostate cancer and significant pretreatment PSA doubling time
From the practice of Dr Roach

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A CME Audio Series and Activity

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