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Case 1 (from the practice of Thomas E Keane, MBBCh):
A 37-year-old man who presented with a PSA level of 37 ng/mL, a palpable prostate nodule and Gleason 4 + 3 prostate cancer.
Case 2 (from the practice of Leonard G Gomella, MD):
A 50-year-old man who presented with an initial-screening PSA level of 47 ng/mL, a 120-g prostate and Gleason 8 and 9 prostate cancer with possible rectal wall invasion
Case 3 (from the practice Michael J Zelefsky, MD):
A 55-year-old man who presented three years ago with T3, Gleason 9 locally advanced prostate cancer with seminal vesicle involvement who refused surgery and hormone therapy
Case 5 (from the practice of E David Crawford, MD):
A 46-year-old man with a strong family history of prostate cancer and an initial PSA level of 15 ng/mL. Ten out of 12 biopsies were positive for Gleason 7 prostate cancer. Radical prostatectomy revealed extensive disease, positive margins and minimal seminal vesicle invasion
Case 6 (from the practice of Mary-Ellen Taplin, MD):
A 50-year-old man who underwent robotic prostatectomy revealing Gleason 8 prostate cancer with seminal vesicle involvement but negative margins
Case 9 (from the practice of Dr Moul):
A 67-year-old man who underwent radical prostatectomy for Gleason 5 + 3 prostate cancer with extracapsular extension and negative margins
Case 11 (from the practice of Dr Roach):
A man in his early fifties with Gleason 6, node-negative prostate cancer and significant pretreatment PSA doubling time